Development and characterization of solid dispersion-based orodispersible tablets of cilnidipine

نویسندگان

چکیده

Abstract Background Cilnidipine, a calcium channel blocker, is the first-line drug for hypertension and belongs to Biopharmaceutics Classification System II. To mitigate its extensive first-pass metabolism improve patient compliance, present study was performed develop characterize solid dispersion-based orodispersible tablets. Results The phase solubility with polyvinyl pyrrolidone 15% has shown 140-fold increase in solubility. X-ray diffraction differential scanning calorimetry studies emphasized conversion of dispersion from crystalline amorphous state. Solid 3 resulted 142-fold improvement solubility, 96% content, percentage release 71.9% at 60 min. F11 containing crospovidone (10 mg) sodium starch glycolate (16 combination higher concentration as super-disintegrants showed least disintegration time 26.6 s. In vitro dissolution results are subjected statistical analysis found that formulation (F11) an increased rate (88.62% 10 min), compared marketed (83% min). Conclusions prepared by solvent evaporation method using PVP carrier can be utilized enhancing cilnidipine. incorporation improves Further, substantiated performing stability vivo future. Graphical

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ژورنال

عنوان ژورنال: Beni-Suef University Journal of Basic and Applied Sciences

سال: 2022

ISSN: ['2314-8543', '2314-8535']

DOI: https://doi.org/10.1186/s43088-022-00259-3